In 25 years as a political professional, Grisolano has worked as a field organizer and leader, a direct mail specialist, a media and research advisor and leading strategist. From January of 2007 to November of 2008, he served as Director of Paid Media and Opinion Research for Obama for America and Obama-Biden 2008.

Grisolano was the lead consultant in the California labor community's successful fight against Proposition 75, the most fiercely contested measure on Governor Schwarzenegger's 2005 Special Election ballot. In 2003, he managed the successful "NO on Prop.54" campaign, which defeated an attempt to roll back affirmative action. He managed Governor Gray Davis' successful 2002 re-election and was in the national spotlight as manager of Californians Against the Costly Recall, the Governor's campaign to defeat the 2003 recall.

In 1992, he worked throughout the country for the Clinton for President Primary Campaign including stints in Little Rock, running the Florida State Convention straw ballot operation, and in the Illinois primary. In 2000, he helped add spark to the Gore Iowa caucus campaign, and in 2004, Grisolano helped John Kerry win the Democratic nomination with a stunning turnaround in the Iowa caucuses.